BioExcel Summer School 2020

First time I ever record a lecture. It was not easy.  Here the lecture part I

and part II 



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Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier

Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier :  Saeedimasine M,  Montanino A,   Kleiven S and  Villa A  Front. Mol. Biosci., 23 June 2021   https://doi.org/10.3389/fmolb.2021.669897 Around half of the traumatic brain injuries are thought to be axonal damage. Disruption of the cellular membranes, or alternatively cytoskeletal damage has been suggested as possible injury trigger. Here, we have used molecular models to have a better insight on the structural and mechanical properties of axon sub-cellular components. We modelled myelin sheath and node of Ranvier as lipid bilayers at a coarse grained level.  Topology and coordinate files for myelin model are deposited in   https://github.com/alevil-gmx/myelin_model . Molecular dynamics simulations were performed to characterize the myelin and node-of-Ranvier bilayers at equilibrium and under deformation and compared to previous axolemma simula...
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